Tokutaro Miki Selected Research

1-O-hexyl-2,3,5-trimethylhydroquinone

10/2017	HX-1171, a Novel Nrf2 Activator, Induces NQO1 and HMOX1 Expression.
1/2015	Single and multiple dose pharmacokinetics and tolerability of HX-1171, a novel antioxidant, in healthy volunteers.
6/2010	Effects of 1-O-hexyl-2,3,5-trimethylhydroquinone on carbon tetrachloride-induced hepatic cirrhosis in rats.
12/2002	Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model.
2/2002	Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats.

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Tokutaro Miki Research Topics

Disease

2	Neoplasms (Cancer) 10/2017 - 02/2002
2	Liver Cirrhosis (Hepatic Cirrhosis) 10/2017 - 06/2010
2	Fibrosis (Cirrhosis) 01/2015 - 06/2010
2	Carcinogenesis 12/2002 - 02/2002
1	Atherosclerosis 03/2002
1	Adenocarcinoma 02/2002

Drug/Important Bio-Agent (IBA)

5	1-O-hexyl-2,3,5-trimethylhydroquinoneIBA 10/2017 - 02/2002
3	Vitamin E FDA LinkGeneric 10/2017 - 03/2002
3	AntioxidantsIBA 01/2015 - 02/2002
1	Carbon Tetrachloride (Tetrachloromethane)IBA 06/2010
1	SolventsIBA 06/2010
1	Peroxynitrous Acid (Peroxynitrite)IBA 06/2010
1	Drinking WaterIBA 06/2010
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 12/2002
1	Sodium NitriteIBA 12/2002
1	Aminopyrine (Aminophenazone)IBA 12/2002
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2002
1	2- amino- 1- methyl- 6- phenylimidazo(4,5- b)pyridineIBA 02/2002
1	benzocycloheptapyridineIBA 02/2002
1	1,2-Dimethylhydrazine (1,2 Dimethylhydrazine)IBA 02/2002
1	Dimenhydrinate (DMH)FDA LinkGeneric 02/2002

Therapy/Procedure

1	Injections 06/2010
1	Chemoprevention 02/2002